ABSTRACT

Training and research Hospital in the two different region, healthy volunteer blood donors were admitted to Blood Bank which serological markers to chronic viral hepatitis HBV, HCV and HDV seroprevalance was investigated by EIA. The aim of this study is to determine seropositivity indicating chronic hepatitis through west and southeast regions and to debate the difference between two regions according to literature.

This study was performed in two groups. First group was enrolled in Sanliurfa between 2004-2006 years, whereas second group was programmed in Bolu between 2007-2009 years. Both of them were taken University Hospital Blood Bank. Healthy blood donors were chosen on a voluntary basis. The serological markers of donors HBV and HCV were studied by macro EIA (Abbott Axsym UK), whereas HDV markers in the sera of patients with HBsAg positive by micro EIA (Abbott UK). All the patients’ ages, professions, birth places and history of transmission were questioned in detail.

In the first group; 565 (2.9%) HBsAg and 104 (0.5%) anti-HCV positive cases were found in a total of 19.250 healthy blood donors. Only 194 HBsAg positive cases were followed and monitories in which 5 (2.5%) ones of all were found to be anti-HDV positive. In the second group including 2012 blood donors, HBsAg and anti-HCV positivity were found respectively 24 (1.19%) and 5 (0.24%) besides no anti-HDV positivity. All subjects’ mean age was 33.9(between 18-71 years).

When comparing population of both Southeast and West cities in aspect of chronic viral hepatitis markers, it is found to be significantly less in West. Previously chronic viral hepatitis seroprevalance is higher in the Southeast region to show decline in recent years and especially in the western region has a remarkable absence of and anti-HDV positivity. We assume that the decrease in the rate seropositivity of chronic viral hepatitis is due to routine immunization and education programs.