E-ISSN: 2147-2939
The Relationship Between Distribution of HCV-RNA and ALT-AST Levels with Genotypes of Hepatitis C Virus Infected Patients
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Research Article
VOLUME: 19 ISSUE: 2
P: 67-70
August 2013

The Relationship Between Distribution of HCV-RNA and ALT-AST Levels with Genotypes of Hepatitis C Virus Infected Patients

Viral Hepat J 2013;19(2):67-70
DOI: 10.4274/Vhd.57966
Özlem KİRİŞÇİ
Ahmet ÇALIŞKAN
Sümeyra ALKIŞ KOÇTÜRK
Pınar ERDOĞMUS
Mustafa GÜL
1.
No information available.
No information available
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ABSTRACT

Materials and Methods:

Blood samples were sent to our laboratory and extracted to yield RNA (Qiagen, Qiasymphony Dsp Virus/Patogen Midi Kit,Germany) and had the RNA quantitation with Rotor-Gene RG-3000 (Corbett Research, Qiagen). Genotyping of samples was carried out with Real Time PCR Reagents Kit (Genome Diagnostics, India).

Results:

In our multivariable analysis, while evaluating the association of the different genotypes with demographic data, we find a notable difference in genotype distribution among genders and it was obviously seen that genotype 1 was common among older patients, while genotype 3 was common among younger subjects.

Conclusion:

This study demonstrated the existence of genotype 1 patients highly prevalant (%60) in our study. Although there was no statistically significant relationship between genotype distrubition and HCV RNA load (p>0.005) and AST levels, ALT levels in group of genotype 3 were significantly higher (p=0.0001).Genotype 1 patients were 60% of all and the results of prevalence rates are consistent with other literature in Turkey.